The article presents information about the latest scientific studies of the connection of the intestinal microbiota with atherogenic dyslipidemia and its participation in the formation of complications from the cardiovascular system. The biomechanisms of the effect of intestinal microflora on the formation of unstable atheromatous plaques in the circulatory bed were considered. The results of our own studies of 60 overweight and exogenous constitutional obesity of the first degree are also presented, the relationship of intestinal dysbiosis with lipid metabolism disorders is shown.