The choice of drug used to facilitate endotracheal intubation in Asthmatic patients during rapid sequence induction (RSI) may have an impact on survival. Ketamine is commonly used in the hemodynamically unstable patient although it has been associated with side effects. This review sought to investigate which induction agents is preferable, and safer for RSI in asthmatic patients. PubMed, Embase, and the Cochrane Library were systematically searched to the end of 2020, for relevant studies to our concerned topic. ketamine is the only available drug that has an analgesic effect itself. All other induction agents are usually combined with an opioid that must be considered a confounding factor, as its more way safe agent in bronchial asthma patients than other agents.