Heterocyclic compounds are those compounds which contain at least one different element, such as oxygen, nitrogen, sulfur, etc. other than a carbon in a ring. Thizaoleis an aromatic heterocyclic compound which means it contains a different element such as nitrogen, sulfur, etc. other than carbon in a ring. Thiazole structure made up of three carbon atoms, with one nitrogen atom and with one sulfur atom which is arranged in the form of a ring.Thiazole comes under the family of azoles which also include oxazoles and imidazoles. Sometimes thiazoles also considered as a functional group. Thiazole is also called 1, 3-thiazole having molecular formula C3H3NS. It is clear or pale yellow in color with a pyridine like anodour.Thiazole is a very important part of vitamin B1, which is also called thiamine. It is also used in flavoring agent and in manufacturing of tobacco related products. Thiazoles are also mainly used in dyes and non-steroidal antiinflammatory drug. Thiazoledyes are mainly used for dyeing cotton. When thiazole fused with benzene ring it becomesbenzothiazole which has various medical importances such as anticancer, antimicrobial, antitubercular, etc. Naturally thiazole found in naturally occurring peptides and these peptides are used in the development of new peptidomimetics.It is generally prepared by the reaction between haloketones and thioamides.Robinson-Gabriel synthesis and Cook-Heilbron synthesis also used for the preparation of thiazoles it includes a reaction between 2-acyclamino-ketones and phosphorus pentasulfide and reaction between α-aminonitrile and carbon disulfide. So keeping in mind we have prepared a review of thiazole and their derivatives having antimicrobial activity.