Background:A substantial proportion of patients with low back pain are categorized as obese and obesity contributes to disability associated with LBP. Various methods have been devised to calibrate the disability index associated with low back pain.The primary outcome of this study was to compare the ODI score between obese and non-obese patients with low back pain undergoing decompression. While the secondary outcome was to compare the pre and post-operative ODI score in obese patients. Methods:After ERC approval and informed consent, a single centre prospective cohort study was conducted over a period of one year from January, 2022 till December, 2022. 50 patients aged 18-70 years with low back pain diagnosed as spinal canal stenosis, prolapsed intervertebral disc or degenerative spondylosis planned for decompression procedure (either by open laminectomy+/- foraminotomy+/- discectomy or fenestration + discectomy) presenting to Neurosurgery department SMBB Institute of trauma were enrolled. The examined factors included the patients’ demographics, co-morbidities, BMI and pre and post operative ODI score which was assessed at three months follow-up of surgical intervention. BMI >30 was considered as obese. Results:The mean age of the patients was 46.74 + 14 years with mean duration of disease was 6 + 3 years. Most of the patients were female 29 (58%) and 21 (42%) males. Among 50 patients, 29 (58%) were obese and 21 (42%) were non-obese. ODI was compared between obese and non- obese patients, significant difference was observed as p-value < 0.05. Significant difference was also observed when pre-surgery ODI was compared with ODI at 1st post-operative day, 2nd week and 3rd month post operative. Conclusion:ODI score remains a precise predictor of disability among patients with LBP undergoing operative intervention and obesity seems to be an inadvertent factor in contributing to disability.