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ISSN 2063-5346
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OPTIMIZATION OF STARCH HYALURONATE AS A NEW SUPER DISINTEGRANT IN THE FORMULATION OF FAST-DISSOLVING TABLETS OF NISOLDIPINE

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Anusha Kusuma, Santosh Kumar R
» doi: 10.31838/ecb/2023.12.3.120

Abstract

Objective:Design and optimization of starch hyaluronate as a new superdisintegrantby employing a 23factorial designin the formulation of nisoldipine fast-dissolving tabletsto increase the bioavailability and patient compliance. Methods:The esterification process was used to prepare starch hyaluronate. The micromeritics and physical characteristics of starch hyaluronate were assessed, and nisoldipinefast-dissolving tablets have been formulated by a direct compression method using starch hyaluronate as a new superdisintegrating agent.Invitro dissolution, invivo pharmacokinetics, and post-compression parameters were assessed. According to ICH requirements, optimized formulation stability tests were carried out under accelerated conditions for six months.

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