Synthesis of 3-amino-1-(5-nitro-1H-indol-2-yl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine-2-carbonitriles by a one-pot green and an eco-friendly reaction of phthalic acid, hydrazine hydrate, indole-3-carboxaldehydes and malononitrile/ethyl cyanoacetate in the presence of Et3N as catalyst and Glycerol mediated at 100-105 oC for 45-60 min. This one-pot reaction proceeded in a short time with good yields and the desired products obtained without using column purifications