This narrative review delves into the critical realm of nursing interventions aimed at enhancing sleep quality in hospitalized patients. The manuscript explores the multifaceted challenges to sleep quality in hospital settings, ranging from environmental factors like noise and lighting to patient-specific issues such as pain, anxiety, and medication effects. A thorough discussion on sleep assessment tools, methodologies, and the pivotal role of nurses in conducting these assessments sets the stage for understanding the complex interplay of factors influencing sleep in hospitalized individuals. The review delineates various nursing interventions categorized into environmental modifications, non-pharmacological approaches, pharmacological considerations, and patient-centered care strategies. Environmental modifications encompass noise reduction strategies, adjustments in lighting and room temperature, and enhancements in bed comfort. Non-pharmacological interventions include relaxation techniques, cognitive-behavioral therapies, sleep hygiene education, and promoting daytime activity. Pharmacological interventions are explored in terms of judicious use under medical supervision and considerations for optimal timing and dosing. Patient-centered care is emphasized through individualized care plans, collaborative goal-setting, and regular communication and reassessment of interventions. Evidence-based outcomes from reviewed studies underscore the effectiveness of these nursing interventions in improving sleep quality and patient satisfaction. Practical implications for nursing practice, including recommendations for integration into care plans, interdisciplinary collaboration, and addressing training needs, are delineated. The abstract encapsulates key findings, implications for practice, research, and policy, and outlines future directions for advancing sleep quality in hospitalized patients through comprehensive nursing interventions.