This review article explores the crucial role of nurses in the implementation of early mobilization protocols aimed at reducing ICU-acquired weakness in critically ill patients. Intensive Care Unit (ICU)-acquired weakness is a common and debilitating complication that significantly impacts the recovery and outcomes of critically ill individuals. The early initiation of mobilization interventions has been shown to mitigate the development of muscle weakness, improve functional outcomes, and reduce the duration of mechanical ventilation and ICU stay. Nurses play a central role in the delivery of these protocols, acting as key advocates, coordinators, educators, and facilitators throughout the mobilization process. This review synthesizes current evidence on the effectiveness of early mobilization strategies, highlights the challenges and barriers faced in their implementation, and emphasizes the importance of interdisciplinary collaboration in optimizing patient outcomes. Furthermore, it discusses the impact of nurse-led mobilization programs on patient safety, comfort, and overall well-being in the ICU setting. By empowering nurses with the knowledge and skills necessary to implement early mobilization protocols, healthcare institutions can enhance patient care quality, promote faster recovery, and reduce the long-term sequelae associated with ICU-acquired weakness.