The number of primary care nurses has not increased proportionately to the rise in care demand. This imbalance has an effect on the health of the professional group as well as the decline in patient safety and care quality. This study aims to investigate the impact of burnout in the nursing staff, and professional fatigue on service quality and safety. It also seeks to distinguish between various research approaches and measurement tools for the phenomenon. A risk associated with the nursing profession, nurse burnout affects nurses, patients, organizations, and society at large. Reduced patient satisfaction, declining safety and quality of care, and nurses' organizational commitment and productivity are all linked to nurse burnout. Burnout is typically seen as a personal problem. Nonetheless, recasting burnout as a collective and organizational phenomenon provides the wider viewpoint required to handle nurse burnout. To ascertain the extent of the correlation between the intense strain faced by Primary Care nurses and the achievement of health objectives for both patients and professionals, additional data is necessary for future research.