A nanoemulsion is a thermodynamically or kinetically stable liquid dispersion made up of two immiscible liquid phases, such as an oil phase and a water phase. The use of a Poly- decalactone Polymer offers a potential strategy to improve this limitation because the technological approach for hydrophilic medium polar drugs is less effective. The formulation that had been optimized using the formulation variables was then further optimized using the process variable. Particle size decreased with changes in stirring time and speed. The optimized formulations have a particle size between 583-615 nm; PDI of0.657±1.8, 0.552±1.05, and 0.734±1.51were selected for loading of the drug for final formulations. The particle size and shape of nanoemulsions were not changed after drug encapsulation. the values of NNE1, NNE2, NNE3, and NNE5 formulation were found to be 6.3±0.04, 7.4±0.08, 6.7±0.06, and 7.0±0.09 units only. In all cases, pH showed the smallest changes. The pH value of the optimized nanoemulsion formulation NNE3 was found to be 6.6±0.06. demonstrating its suitability for oral administration. Drug entrapment efficiencies of different formulations i.e. NNE1, NNE2, NNE3, NNE4, and NNE5 were found to be 71.33±1.62%, 82.4±0.24%, 99.95±1.35%, 90.12±0.34%, and 79.03that showed to affect the encapsulation of drug. Stability studies were carried out at 40C and 250C.