To evaluate comparison of Nifedipine and magnesium sulphate for treating preterm labor. Material and methods: A total of 200 subjects with presence of preterm labour between twenty-four weeks to thirty-seven weeks of gestation. Pregnancies that were nulliparous or multiparous, had intact membranes, and displayed clinical indicators of premature labour met the inclusion criteria. Randomization of all the patients was done and all the patients were divided into two study groups- Nifedipine group and magnesium sulphate group. The success of tocolysis treatment and its side effects were evaluated in all patients who had not given birth forty-eight hours and more than 7 days (secondary tocolytic effects) after starting it. All the results were recorded in Microsoft excel sheet and were subjected to statistical analysis using SPSS software. Results: Mean maternal age of nifedipine group and magnesium sulphate group was 31.5 years and 30.1 years respectively. In the nifedipine group, there were 5 patients who delivered after 24 hours, 10 patients who delivered after 48 hours, 5 patients who delivered after 72 hours, and 55 patients who delivered after 7 days. In the magnesium sulphate group, there were 8 patients who delivered after 24 hours, 8 patients who delivered after 48 hours, 6 patients who delivered after 72 hours, and 60 patients who delivered after 7 days. There was no statistically significant difference between the two groups with regard to this quality. Conclusion: We concluded that the oral nifedipine is a suitable alternative for magnesium sulfate with the same efficacy and side effects in the management of preterm labor