For the validation of Lafutidine and Rabeprazole, each in their unique structure and as tablets, a speedy and fruitful contrary stage elite execution fluid chromatographic method has been communicated. For the chromatography, methanol used to be mixed with a Phenomenex Gemini C18 (4.6 x 250 mm) 5 fragment. The ID was once carried out at 230 nm with a floating fee of 1.0 ml/min with the use of a TEA Pad (65:35 v/v) as the sensible stage. Lafutidine and Rabeprazole had a quick resource season of 2.121, and 3.643 0.02min, respectively. For Lafutidine concentrations between 10 and 50 mg/ml and Rabeprazole concentrations between 20 and one hundred mg/ml, the technique yields linear responses. The method's RSD for the size declaration used to be 2% or less. This shape is useful for making sure of constant mass and remedy definitions.