Objective: The objective of this research is to use a natural modified starch obtained from Aponogeton natans to improve the solubility and bioavailability of glipizide, a BCS class II drug. Methods: Aponogeton natans starch was isolated and modified into starch citrate form by interacting with citric acid at high temperatures. The physio-chemical characteristics of starch citrate shows that it is water insoluble, has good flow characteristics, and a high swelling index without gelling properties. Drug and starch citrate compatibility was demonstrated using FTIR and DSC spectra. The solid dispersion of glipizide with Aponogeton natans starch citrate was prepared by solvent evaporation method with varying proportions such as 1:1, 1:2, and 1:3. Results: The results show that the drug content of all formulations is more than 99 %.In vitro dissolution study reveals the F6 formulation exhibits more than 90% drug dissolution within 30 minutes .Bioavailability study of F6 formulation shows greater AUC and Emax value than pure glipizide. The F6 formulation was then compressed and formulated into an IR tablet by direct compression method. The tablets are then put through a series of quality control tests. In vitro dissolution study of tablet reveals that over 90% of the medication is dissolved in 30 minutes.% DE 30 was found more than 99% in 30 minute. Lowest time of T50 was observed for F10 i.e. 7.36 min indicating higher dissolution potential of starch citrate based immediate release tablet. Conclusion: The research showed that tablet prepared with starch citrate of Aponogeton natans shows improved dissolution and has higher bioavailability