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ISSN 2063-5346
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MIXED HYDROTROPIC SOLUBILISATION- A NOVEL TECHNIQUE TO ENHACE THE DISSOLUTION OF FEBUXOSTAT

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Megha Verma, Kaminee Sahu, Ankita Singh Alice, Anupam Jaiswal, AbhilashaSingh,Stuti Pandey
» doi: 10.48047/ecb/2023.12.si4.424

Abstract

The aim of this study was to improve the dissolution of water insoluble drug by mixed hydrotropic solid dispersion technology. The poor dissolution characteristic of water insoluble drugs is a major challenge for pharmaceutical professionals. Mixed hydrotropic solid dispersion (HSD) technology contains the blends of hydrotropic agents, gives synergistic effect on solubility of poorly aqueous soluble drug. This technique restrict the use of large amount of individual hydrotropic agent, thus minimize the toxic effects of individual hydrotropic agent arising due to their high concentration. HSDs were prepared by using hydrotropic blend of 15% sodium benzoate, 10% Niacinamide and 5% sodium citrate by solvent evaporation method.Hydrotropic agents previously evaluated for their compatibility with drug by FT-IR study. Prepared solid dispersions were evaluated by XRD and dissolution studies, compared with the pure febuxostat power and physical mixture of drug and hydrotropic agent. The result showed no interaction between the drug and hydrotropic polymer and significant increase in the dissolution rate

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