The present work deals with the sequence of Indazole, Triazole and Indole-2-one fused novel Azole derivatives MNSR-3(a-l) was synthesized by microwave assisted method, and were screened as potential anticancer, antibacterial activities and molecular docking studies. All of the newly synthesized compounds structurally characterized on the basis of IR, 1HNMR and Mass spectral analysis. Further, were screened for antibacterial activity was carried out by agar diffusion (Cup plate) method by using Streptomycin as standard and anticancer activity against MCF-7 cell lines by MTT assay method. The results showed that some of the compounds MNSR-3c and 3i exhibited good anticancer activity and MNSR-3c, 3f, 3h and 3l are exhibited potential antibacterial activity by comparing standard drug. Additionally, the molecular docking studies of Indole, Triazole and Indole-2-one fused novel Azole derivatives was carried out to explain putative bonding interaction between the active site of EGFR enzyme and potent inhibitors by Schrodinger suite.