Drug release was retarded with an increased in polymer concentration due to the gelling property of polymers. The in-vitro drug release from proposed system was best explained by the Higuchi’s model indicating that the release of drug from tablets displayed diffusion controlled mechanism. The aim of this study was to improve the dissolution rate of Ibuprofen release the drug in controlled manner over a period of 24 h. Matrix tablets were prepared by direct compression method, using hydrophilic polymers (HPMC/ guar gum). Matrix tablets were prepared by wet granulation method using different concentration of hydrophilic polymers (HPMC/ guar gum).Tablets were evaluated for in-vitro drug release profile in phosphate buffer, pH 6.8, (without enzymes).Drug release was retarded with an increased in polymer concentration due to the gelling property of polymers. The in-vitro drug release from proposed system was best explained by the Higuchi’s model indicating that the release of drug from tablets displayed diffusion controlled mechanism.