A standard delivery technique is utilised to provide the majority of pharmaceuticals used to treat various illnesses, which are often taken orally. Due to its weak water solubility, chemical stability, and pre-systemic metabolism, oral dosage has a low bioavailability. Pharmaceuticals with low solubility and bioavailability in water pose a challenge to formulation experts. One of the new technologies created to solve these issues is lipid-based medicine delivery systems (LBDDS). Increased bioavailability can be achieved by encapsulating or solubilizing the drug in lipid excipients, which can also aid in solubilization and absorption. In this study, we seek to better understand the novel delivery methods that have been created for enhancing the oral bioavailability of pharmaceuticals with limited water solubility, as well as the role that solid lipid nanoparticles play in the pharmacokinetics of such compounds. Solid lipid nanoparticles may provide novel possibilities for the treatment of hypertension with enhanced oral delivery if thoroughly investigated.