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ISSN 2063-5346
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METHOD DEVELOPMENT AND VALIDATION OF DARUNAVIR AND RITONAVIR DRUGS BY THE APPLICATION OF GREENER CHROMATOGRAPHIC TECHNIQUE

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B. Prakash kumar1*, T Y Pasha. 2 , B Ramesh3
» doi: 10.48047/ecb/2023.12.si5a.0223

Abstract

Traditional methods used for the analysis of pharmaceutically active compoun- ds require large volumes of organic solvents and generate large amounts of waste. The main aim of green analytical chemistry is to find new analytical methodology or to modify an old method to incorporate procedures that use less hazardous chemicals. There are several methods is available to achieve this goal such as using environmentally benign solvents and reagents, reducing the chromatographic separation times and miniaturization of analytical devices. Green chemistry which is mainly based on the principle where the usage or generation of hazardous chemicals or substances is minimized. It's also called as programmed chemistry in chemistry and related areas. In modern analytical chemistry, the development of greener methods necessitates considering the green aspects at the stage of method development The main aim of the Green chromatography is to reducing the amount of the toxic chemicals consumed and wastages generated during the method development. Green solvents or the bio solvents which are more environmental friendly and cost effective compared to the petrochemicals is recommended the solvents like ethyl acetate and ethanol [1]

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