View of the importance of implantable antennas in both the technical and medical fields, they have attracted a lot of interest. Such implantable systems are being used in a wide range of medical procedures, including the detection of tumors, wireless patient monitoring, the detection of different cancers, verbal detecting, self-monitoring, gastrointestinal monitoring, retinal implants, and cardiac valve defibrillators and pacemakers, temperature monitoring, and orthopedic monitoring devices. The use of remote health monitoring systems, which have decreased face-to-face consulting, is primarily lowering delays in hospitals. Due to their tiny size, patch antennas are suited for integration with implanted devices. The present paper reviews the gain enhancement of a patch antenna integrated with a metamaterial-inspired superstrate. The review article discusses a brief introduction to the antenna, then discusses the patch antenna (such as types, applications, limitations, and parameters of patch antenna) followed by different feeding techniques, Reconfigurability, Relevant literature studies on the current topic, introduction to HFSS, metamaterials, solution methodologies, and ANSOFT HFSS electromagnetic simulation