Calotropis procera, commonly known as Apple of Sodom or Sodom's milkweed, is a medicinal plant with a long tradition of utilization in conventional medicine. Africa, Asia, and the Middle East all contain tropical and subtropical regions home to this plant. Alkaloids, flavonoids, terpenoids, glycosides, and tannins are among the phytochemicals that contribute to Calotropis procera's medicinal properties. Calotropis procera has been shown to have a wide range of pharmacological properties, including anti-inflammatory, analgesic, antimicrobial, antitumor, antifungal, antioxidant, and immunomodulatory properties. Other properties include its ability to reduce pain. The plant has been used to treat asthma, malaria, diabetes, cancer, and a number of other conditions. Due to the presence of certain compounds that stop the growth of various cancer cells, such as calotropin, calotropagenin, and uscharidin, Calotropis procera has been found to have potent antitumor activity. Additionally, the plant's immunomodulatory properties suggest it could be used to treat autoimmune conditions. The mitigating properties of Calotropis procera make it a promising possibility for the treatment of different incendiary sicknesses like rheumatoid joint pain, ulcerative colitis, and asthma. Certain compounds in the plant reduce the production of pro-inflammatory cytokines and inhibit the activity of inflammatory enzymes. Calotropis procera's ability to lower blood glucose levels by stimulating the production of insulin may also be responsible for its antidiabetic activity. In addition, the plant has been found to have antioxidant activity, which shields the body from oxidative stress and may be useful in the treatment of a variety of diseases like cancer, neurodegenerative disorders, and cardiovascular diseases. In general, Calotropis procera is a promising medicinal plant with the capacity to treat a variety of diseases. To fully comprehend its mechanisms of action and to develop safe and effective therapies based on its medicinal properties, additional research is required.