Since the beginning of human civilization, several plant species have been used in the production of medicinal products. Our relationship with the natural world predates the beginning of human civilization, and for thousands of years, people have been looking to the outdoors for healing remedies. People are increasingly becoming more aware of the harmful consequences that antihypertensive drugs may have, in addition to the importance of having herbal plants and ayurvedic remedies readily available in their immediate surroundings. So, the present study aimed to ethno botanical survey of district Hisar, Haryana and to enlist the plants used for hypertension and cardio-vascular disease. The data was collected through field surveys and in-depth interviews organized with different local informants from the region during July, 2021 to August, 2022. A total of 55 medicinal plants useful for heart disease belonging to 39 families were collected from different selected study sites. Families such as Solanaceae and Asteraceae were found to be dominant with maximum 4 genera followed by Apocynaceae and Asparagaceae with 3 genera. Majority of plants were herbs (29) followed by shrubs (12), trees (9) and climbers (5). The most commonly used plant parts were leaves and fruits. According to the findings of this study, the plant variety found in the region of Hisar district is rich in medicinal plants, particularly those that are utilised for the treatment of hypertension and other cardiovascular diseases. Thus, these types of sites can be considered useful for pharmaceuticals for development of herbal drugs in future.