In the recent times, in situ based gel drug delivery systems that can transport therapies to the appropriate region, circumvent the blood-brain barrier, lower peripheral toxicity, and regulate drug release kinetics have been established. The bioavailability of several medications used to treat neurological illnesses is poor. The use of in situ gels for medication delivery to brain through nose-to-brain pathway has shown considerable assurance in preclinical studies from a number of pharmaceutical scientists. However, in the development of these gels, safety concerns including the toxicity of nasal mucosa, drug delivery to specific brain regions, and dose estimation are aspects that must be taken into consideration. The in situ-based gels employed for therapeutic drug administration from the nose to brain, as well as preclinical studies and difficulties, will be mainly given emphasis in this review.