Variety of plant parts are used in medical health science owing to its benefits such as anti-inflammatory, antiinfective, antioxidant, antitumorigenic effects. Bioingredients present in it have specific therapeutic potential. Integration of these constituents into dental biomaterials has shown interesting outcome to treat many diseases. In dental material science research, several plant parts are added to achieve superior properties. Till date, there is scarce literature that showed the major challenges while adding the constituents. Definitive remarks regarding its sustainability are yet uncertain. This article discusses on the many difficulties encountered during the incorporation of plant products into denture polymers.