This research aims to investigate the applicability and significance of Six Sigma and Lean Six Sigma methodologies within the health sector, with a particular focus on clinical laboratories. The study aims to identify and explore the relevance of these quality improvement frameworks in enhancing efficiency and patient care in healthcare settings. Additionally, the research seeks to identify the potential facilitators that could support the successful implementation of the Lean Six Sigma model in selected hospitals across Kerala, as well as the constraints that may hinder its adoption. Through a comprehensive analysis of these facilitators and constraints, the study endeavors to develop a tailored Lean Six Sigma model that aligns with the specific requirements and challenges faced by healthcare institutions in Kerala. The findings from this research paves the way for optimizing healthcare processes, minimizing errors, and improving overall quality and patient outcomes in clinical laboratory settings and other healthcare facilities in the region.