Background: Insomnia, which may have an effect on the illness's progression, is a symptom of a set of hereditary autosomal recessive hemolytic diseases, including thalassemia and sickle cell disease (SCD). The purpose of this research was to investigate the prevalence of insomnia and the factors that are associated with it in children who suffer from transfusion-dependent forms of hemoglobinopathies. Subjects and Method: A descriptive research design was utilized. Setting: Children Hospital of Mansoura University. Subjects: The studied subjects consisted of 405 children whom selected from above mentioned setting. Tools: Two tools were used to collect the data of study through First: - Socio-demographic characteristics and clinical data of the children and Second: - the Insomnia Severity Index (ISI) Third: - Hospital anxiety and depression scale (HADS). Results: The research found that the average age of the children under observation was 11.22 years old, with a standard deviation of 2.39 years. More than 56.3% of the children under observation required blood transfusions. Almost one third of the people who participated in the study (28.40%) had a very severe degree of insomnia, and approximately half of the people who participated in the study (47.90%) had a moderate level of insomnia. There werepositive correlation between Eating habits, Social Interaction, Recreational activities, Anxiety and Depression and Insomnia. Conclusion: The current study concluded environmental, psychological, and medical and treatment factors were factors causing insomnia among children with Transfusion-Dependent Hemoglobinopathies. Recommendations: It is important to conduct an assessment of insomnia in children who have transfusion-dependent hemoglobinopathies in order to determine its pattern, factors that affect sleep disturbances, and how a health education programme should be designed and provided for children who have transfusion-dependent hemoglobinopathies, as well as their carers, about the factors causing insomnia in children who have transfusion-dependent hemoglobinopathies and how to deal with them.