Challenges encountered in the efficient delivery of drugs are multi-dimensional ranging from solubility issues to the first-pass biotransformation to P-gp efflux-based removal of drugs. Most drugs suffer from one or more of these problems. There are varieties of ways to overcome them. This article provides a comprehensive review of one such approach called “selfies”. Selfies are self-emulsifying systems that have the ability to convert into an emulsion with extremely fine droplets of micron or nano sizes. Thereby they give all the benefits of emulsions without the inherent stability issues associated with the dosage form. This review is designed to help formulators see the multifaceted personality of these systems. It is going to highlight the differences between the different selfies, elaborate on the various excipients that are available to make a system as you envision functioning, reflecting on the various applications for which these versatile systems have been used thus far, the assortment of dosage forms into which they have been converted for ease of delivery and lastly, it would focus on the opportunities that lay ahead if one opts for these systems. This would also provide unique areas of research which are hitherto still questions largely unanswered