Background: Despite recent advances in dialysis techniques, the high mortality of end-stage renal disease (ESRD) patients remains a major challenge, with most patients depending on haemodialysis (HD) to replace renal function. Intradialytic hypotension (IDH) is one of the most common complications of HD in clinical practice due to the older average age of dialysis patients and the increasing prevalence of comorbidities such as diabetes mellitus and heart failure (HF). The aim of our study was to assess influence of Rate of ultra-filtration and L- carnitine on Intra dialytic hypotension on Regular Hemodialysis Patients.