The study is an endeavor to evaluate influence of practice on doctors’ behavior towards genericmedicines limiting its mass use. Practice, one factor amongst several, was chosen to evaluate doctors’ behavior towards generic medicines. Rising healthcare cost is drawing serious interest towards generic medicines from majority of the countries, developed or developing. In India, out of pocket expenses towards healthcare costs are one of the highest in the world. Besides, affordability is another major challenge in bearing healthcare cost due to its demographics. The alternative to expensive branded medicines is generics, the much talked about in recent times. Generic medicines are being promoted by the government of several countries, doctors in India are being advised to write prescription in generic names. However, there are several challenges in acceptance and usage of generic medicines.