The treatment of hyperglycemia - diabetes mellitus, herbal medicinal substances clearly differ from synthetic chemical preparations in that they have few side effects and can be used for a long time. But since the effect is relatively weak, the possibility of using them at the right time is relatively small. The most oral preparations are mainly xenobiotics, their use is somewhat limited due to side effects. To isolate hypoglycemic substances from medicinal plants, to create effective antidiabetic drugs on their basis by identifying the mechanisms of influence on biochemical processes are given in this article.