This study aims to determine the effectiveness of medical surgical nursing clinical learning with digital literacy in increasing the creativity of students in the nurse profession program. In this research, a quasi-experimental design with a quantitative approach was employed. The study involved two distinct groups, with the intervention group exposed to medical surgical clinical learning with digital literacy, while the control group received conventional learning. The intervention period lasted eight weeks. The data was collected through tests and questionnaires that aimed to elicit information on students' experiences, perceptions, and suggestions for enhancing the learning experience. To analyze the collected data, descriptive and inferential statistical techniques were employed. The investigation's findings suggest that implementing Medical Surgical Nursing Clinical Learning with Digital Literacy resulted in a discrepancy in the mean creativity scores between the intervention and control groups. Therefore, the use of Medical Surgical Clinic Learning with Digital Literacy may enhance nursing students' creativity within their professional education.