Retinoblastoma is a malicious intraocular tumour common in children, accounting for around 4% of all childhood cancers. Light is detected by the retina, a thin layer of nerve cells, which then transforms it into nerve signals that are sent to the brain through the optic nerve. The incidence of the retinoblastoma is due to the biallelic deletion of the RB1 gene as well as other genetic and epigenetic changes that leads to cancer growth. The absence of RB1 causes retinoblastoma cells highly vulnerable to malignant transformation. Chemotherapy has improved treatment outcomes