Cancerous cells show altered expression of several genes which involves activation of transcription factors and/or inactivation of transcriptional regulators. Several metabolites are known to aid cancerous growth. Isocitrate dehydrogenases (IDH-1 and IDH-2) have been found to be mutated in cancers like gliomas and chondrosarcomas. These enzymes are known to affect the transcription profile of cancerous cells. However, how a metabolic enzyme mediates the transcriptional regulation is an area open for investigation. Here we report a possible mechanism of movement of a metabolic enzyme from cytosol to the nucleus to alter the transcription profile of a cancerous cell.