According to the results which obtained in this study the design and synthesis of Schiff compounds were produced b simple and rapid reaction, the results showed that some of Schiff base compounds gave antibacterial and anti-fungi activities , compounds(1,2,3 and 5) exhibit antimicrobial activity, On the other side the compounds of (1,2,3,4 and 5 displayed significant activity against Bacillus. The similar compounds (1,2,,3 and 5) provided inhibition zone against Rhizopus Fungi. Also the results indicated that the high concentration of 100 %showed high inhibition zone comparing with the other applied concentration