The purpose of this research is to provide the findings of a study of immunoglobulins A, M, G, and fetuses in pregnant women who had COVID-19 with both a moderate and severe course of the disease. In 2022, the Republican Perinatal Center conducted immunological research on 70 fetal cord blood sera obtained by transabdominal cordocentesis in pregnant mothers with COVID-19. Pregnant women are categorized into three categories. Group I (control) consists of pregnant women with physiological pregnancy (n=10), whereas Group II consists of pregnant women who had COVID-19 in the second trimester of their pregnancy (n=30). Group III consists of pregnant women who had COVID-19 in the third trimester of their pregnancy (n=30). The Institute of Immunology was the site of all immunological research. The level of IgG in the blood of fetuses against the background of severe COVID-19 of the mother was significantly increased by 2.3 times and 2 times compared to the control group in the II and III trimesters. The content of IgM in fetuses against the background of a severe course of COVID-19 in mothers was significantly increased compared to the control data by 2 times both in the II and III trimesters. With an average course of the disease, the indicators of all immunoglobulins A, M, G, in fetuses were not significantly changed compared to the normative data in both the II and III trimesters. In pregnant women who underwent COVID-19 in severe form both in the second trimester and in the third trimester of gestation, the synthesis of immunoglobulins by the fetus increases due to IgG and IgM, which are the result of the immunological response of the fetus