This revision was considered to explain the influence of oral administration of lercanidipine on the livers and kidneys of pregnant female rats during stages (16, 20) days of pregnancy, The current study was carried out in the animal house of the College of Science at the University of Kufa, starting from 1/10/2022 to 1/3/2023.The total number of rats used in this experiment is 45 male and female albino rats, about 15 of which were fertile male rats for the purpose of mating only And 30 adult female rats , and after mating between female and male rats and the occurrence of pregnancy and obtaining a sufficient number of pregnant rats, which were (30) pregnant rats. It was divided into 3 main groups, each of which contained 10 pregnant rats. The first group represented a control group and was dosed with physiological saline only, The second group was dosed with lercanidipine at a concentration of 10 mg/kg of body weight, while the third group was dosed with lercanidipine at a concentration of 20 mg/kg of body weight, The females were dosed orally from the first day of pregnancy in one dose per day. After the end of the experiment, five pregnant rats from each group were neutered during the gestation period (16) days, while the other five were neutered during the (20) day of gestation. Statistical analyzes recorded a significant decrease (P < 0.05) in the weights of livers and kidneys in groups of pregnant rats that were treated with lercanidipine at two concentrations of 10 mg/kg and 20 mg/kg during the gestation period of 16 and 20 days, respectively Compared with the weights of livers and kidneys of pregnant rats for control groups and for the same gestational periods (16 and 20) days, respectively The histological results of this study revealed that treatment of pregnant females with lercanidipine during pregnancy caused histopathological changes in the histological structure of the livers of pregnant rats Represented by (Central vein wall rupture, hepatocellular necrosis, enlarged sinusoids) during pregnancy 16 days While the changes were observed (Destruction of the wall of the central vein and changing its shape and width, enlargement of sinusoids, necrosis and degeneration of hepatic cells, necrosis of the hepatic tissue and infiltration of inflammatory cells) during the gestational stage 20 days of pregnancy, compared with the histological composition of the liver of pregnant rats in the control groups and during the same two periods of pregnancy above respectively The results of the microscopic examination of the histological structure of the kidneys of pregnant females during the gestation period of 16 days showed that these changes were (shrinkage of the renal glomerulus, widening of Bowman's space, necrosis of the cells of the inner lining of the urinary tubule) These pathological effects increased in the kidney tissues during pregnancy (20) days (renal tissue necrosis, hemorrhage, inflammatory cell infiltration, blood clotting) Comparison with the histological structure of pregnant females in the control groups for the two gestational periods (16 and 20) days, respectively, in which the histological structure was normal.