The objectives of this research were: 1) to study the current situation of high-level talents at university in Guangxi 2) to develop the guidelines for development of high-level talents at universities in Guangxi, and 3) to evaluate the adaptability and feasibility of guideline for development of high-level talents at university in Guangxi were including 4 following aspects: 1) family factors, 2) educational factors, 3) social factors, and 4) personal factors. The sample group of this research were 200 high-level talents from top 20 public universities in Guangxi, determined by stratified sampling method. The research instruments were questionnaire, interview form and evaluation form. The statistic to analyze the data were percentage, mean, standard deviation and contents analysis. The result was found that the current situation of high-level talents at university in Guangxi was at high level. Considering the results of this research aspects ranged from the highest to lowest level were as follow: the highest level was educational factors, followed by social factors, and family factors was the lowest level. The guidelines for development of high-level talents at universities in Guangxi consisted of four aspects: 1) family factors, 2) personal factors, 3) social factors, and 4) educational factors. Evaluation of the adaptability and feasibility of guideline for development of high-level talents at university in Guangxi was at high level.