Sickle-cell disease (SCD) is a group of blood disorders which is inherited from the parents. It is known that the sickle cell neonates have a normal weight at birth. However, the disease with its attendant increased energy requirements has a negative effect on growth with a slow prepubertal growth and a delayed velocity compared with normal children. Previous studies of children with sickle cell disease (SCD) reported poor growth and delayed maturation. Physical growth is known to be impaired in children with sickle cell disease and the prevalence and severity vary with geographical location. The factors which contribute to this sub-optimal growth are poorly understood. This study was undertaken to provide additional data on the growth and maturation status of children with this disease. Aim and Objectives: To study growth profile in children with sickle cell disease who are on treatment of hydroxyurea and children with Sickle Cell Disease. Material and Methods: This study was a Prospective Observational study. This study was conducted in special clinic [haematology clinic], department of paediatrics, Pipriya From day of permission to one year. 50 patients were included in this study