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ISSN 2063-5346
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Green Synthesis, Characterization and Antibacterial Potential of Zinc Oxide Nanoparticles Synthesized from Bryophyllum pinnatum (Lam.) Oken Leaf Extract

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Molla Fentie Tassew, Priya Tyagi, Garima Chouhan
» doi: 10.31838/ecb/2023.12.si4.202

Abstract

Antibiotic resistance is a public health issue since it might result in treatment failure. Despite being susceptible to a wide range of antibiotics, Listeria monocytogenes has developed resistance to several conventionally used antibiotics. Alternative therapeutics that can either complement or replace antibiotics is highly desired to resolve the issue of drug resistance. Thus, the search for antibacterial agents against such emerging drug-resistant bacteria is currently an area of research worldwide. In this regard, several green synthesized nanoparticles have been known to exhibit for their antibacterial properties and, therefore, may aid in alleviating the problem of bacterial resistance in Listeria monocytogenes. Therefore, the present study aimed at the evaluation of the antibacterial potential of Bryophyllum pinnatum (Lam.) Oken leaf extract mediated zinc oxide nanoparticles (ZnO-NPs) against Listeria monocytogenes. ZnO-NPs synthesis was confirmed using UV-Visible spectroscopy, Scanning Electron Microscopy (SEM), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and Dynamic Light Scattering (DLS) techniques and the antibacterial activity was evaluated against Listeria monocytogenes using agar well diffusion method. Spherical shaped ZnO-NPs with an average crystalline size of 34.62 nm were prepared. The prepared ZnO-NPs have shown good antibacterial activity against Listeria monocytogenes. Hence, from the present work, it could be concluded that Bryophyllum pinnatum mediated ZnO-NPs can be used as potential antibacterial agent for treating Listeria monocytogenes-related infections. However, more research work is needed to figure out the mechanism of action of the synthesized nanoparticles against the target microbe.

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