The polyphenolic substances found in fruits, vegetables, and certain medicinal plants are called flavonoids. The bioactive chemicals found in the root of Scutellaria baicalensis, which include Wogonin, Scutellarein, Baicalein, and Baicalin, have long been utilised in traditional Chinese herbal therapy. Wogonin has been shown to have a wide range of biological effects in both laboratory and human settings, including anti-cancer, antiinflammatory, and anti-bacterial and anti-viral effects. In this article, we will discuss the therapeutic effects of Wogonin, including its antiviral, anti-inflammatory, neuroprotective, anxiolytic, and anticonvulsant properties. Also, the molecular mechanism(s) by which Wogonin modulates cellular signal pathways and immunological responses are reviewed, and the beneficial qualities of Wogonin in a variety of therapeutic contexts are emphasised.