Introduction: Liver dysfunction has been recognized early as a critical risk factor. As a result, patients with liver dysfunction are rarely included in these databases, presumably because surgeons have understood this risk and abstained from routinely operating on these patients. Objectives: The main objective of the study is to find the frequency of liver dysfunction after cardiac surgery. Methodology of the study: This cross-sectional study was conducted in Armed forces Instituted of cardiology / National Institute of Heart Diseases, Rawalpindi from January 2024 to April 2024. Data were collected from 245 patients with cardiac surgery, including coronary artery bypass grafting (CABG) and valve replacement. Data were collected through a designed questionnaire. Patient information such as demographics, background conditions, current state within the operating room, postoperative recovery was obtained from the Electronic Medical Records system. Results: Data were collected from 245 patients according to inclusion criteria of the study. Among the 245 patients included in the study, 45 (18.4%) experienced liver dysfunction following cardiac surgery, defined as elevated liver enzymes exceeding three times the upper limit of normal within the first 7 days postoperatively. The study observed significant alterations in various laboratory parameters between the preoperative and postoperative periods among patients undergoing cardiac surgery. Postoperatively, there was a notable increase in liver enzymes, with alanine transaminase (ALT) rising from 25± 10 U/L to 75± 30 U/L and aspartate transaminase (AST) from 30±12 U/L to 80 U/L (± 35), suggesting hepatic injury or stress. Conclusion: It is concluded that liver dysfunction following cardiac surgery is a significant complication, affecting approximately 18.4% of patients in this study. Advanced age, longer CPB duration, and higher BMI were identified as independent predictors of liver dysfunction.