The anti-inflammatory drug piroxicam (PXM) is used to treat inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and others. It is said that when taken orally, it might lead to peptic ulcers, edoema, ulcerative colitis, and gastrointestinal discomfort. So, the ethosome was developed as a substitute delivery mechanism. The present study describes the preparation, characterization, and optimization study of piroxicam-loaded ethosomes using 32 factorial designs. Ethosomes were produced using the cold technique and then examined for FTIR studies, zeta potential, % entrapment efficiency (%EE), and particle size