The niosomes are organized using thin-film hydration and sonication techniques. For the film hydration method, dissolve surfactant, cholesterol, stearylamine (65.0:30.0:5.0 mM) and captopril (2 mg) in aggregates containing chloroform:ethanol (3: 1). The solvent was evaporated under vacuum on a rotary evaporator to form a thin film. Using a stirrer, replace the membrane then hydrate with 10 mL of phosphate buffer (pH 7.4). For ultrasonic techniques, surfactants, cholesterol, stearylamine (65.0:30. 0:5.0 mM) and captopril (2 mg) were mixed in a beaker, and 10 ml of phosphate buffer (pH 7.4) was added. I left it for five hours. White dispersions (niosomes) were synthesized 7 min before sonication as needed. In the ether injection technique, a solution containing a mixture of ether and surfactant is introduced slowly into an aqueous solution (preheated to 60°C) to evaporate the ether and synthesize a milky paste. The products were thus analyzed for a number of parameters, including percent encapsulation efficiency, vesicle length, polydispersity index, and zeta capacity, and were determined to be state-of-the-art. technology for making niosomes based on this specification.