This study aimed to design a mouth dissolving tablet (MDT) of Nadolol It is an Antihypertensive drug that is widely used in hypertension. It is a poorly water-soluble drug (0.14 gm/ml) at pH 1.7 in solubility. Thus, the attempt was made to enhance the water solubility by using the solid dispersion. Drug and disintegrant solid dispersion at a specific amount of mixture. By this method of preparing mouth dissolving tablets for Nadolol which dissolve rapidly in the mouth using Crosspovidone as the disintegrating agent. The solid dispersion technique (Solid dispersion) was used to enhance the solubility of Nadolol. Different Novel & regularly used superdisintegrants such as Croscarmellose sodium, Sodium starch glycolate were used respectively.