Oral drug delivery is the easiest and most basic way to provide medication. Nevertheless, low and irregular bioavailability, which is mostly due to poor water solubility, is the fundamental issue with oral medication formulations. For medications that are not extremely water-soluble, dissolution is the phase of the absorption process that is rate-limited. Due to inconsistent or insufficient absorption from the GIT, bioavailability issues are common with very hydrophobic medicines (aqueous solubility of 0.1 mg/ml at 37°C). One of the most alluring and promising methods to enhance the inadequate aqueous solubility of pharmaceuticals is the solid dispersion spray drying technology combined with oral dispersible tablets.Cilnidipine is a marginally water-soluble antihypertensive drug (BCS II). Making the medicine more soluble was the aim of this experiment. The development of a cilnidipine fast-dissolving tablet was attempted. The study's designs aim to increase the drug's bioavailability and hasten the beginning of action.