Dental caries, one of the globally affecting diseases of the oral cavity and the herbal extracts in clinical practice can benefit the oral hygiene of the patient. The main instigation and progress of dental caries involve acidogenic and aciduric Gram-positive bacteria such as Streptococcus, Lactobacillus and Actinomycetes colonizing the supragingival biofilm which impede with usual nutrition intake, verbal communication, selfworth and daily habitual behavior. Mimosa pudica (from Latin: pudica “shy, bashful or shrinking”.) is a creeping annual or perennial flowering plant of the pea/legume family Fabaceae, often grown for its curiosity value: the compound leaves fold inward and droop when touched or shaken, defending themselves from harm, and re-open a few minutes later. The in vitro study shows that the ethanolic extract of M. Pudica is present flavonoids and tannins contain and the greatest zone of inhibition study indicates anti-bacterial and antiinflammatory activity.