Verapamil Hydrochloride is a Cardio-Vascular calcium channel blocking agent preferably used to treat high blood pressure and Cardiac Arrhythmia. On its oral administration 90% is absorbed and only 20-30% of the drug is available systemically. The present aim of the work is to prepare the suitable dosage vehicle for the transdermal delivery of Verapamil Hydrochloride. The ufasomes are proved to be good vesicles for the delivery of the drugs through transdermal route. They are effective in transporting the drug through stratum corneum which is superficial barrier in the transdermal drug delivery. Oleic acid is indulged for the formation of drug vesicles by thin film hydration technique. Other, excipients used are cholesterol and glyceryl mono stearate. The prepared Ufasomes are evaluated for different parameters like Entrapment efficiency, Zeta potential, Poly dispersity index, TEM studies, In-vitro diffusion and Drug release kinetics. The drug release studies of all formulations were conducted for 12 hours. Among the 9 formulations F5 have the better drug entrapment efficiency of 74.3% and mean particle size of 321.6 nm of drug release of 79.40% at end hour. By this we conclude that formulation F5 was chosen as the best formulation. Kinetic release study of release data in best curve-fitting method of drug Verapamil hydrochloride shows Zero order kinetics stating that the release of the drug from dosage form doesn‟t depends on its concentration.