.

ISSN 2063-5346
For urgent queries please contact : +918130348310

FORMULATION AND EVALUATION OF VESICULAR DRUG DELIVERY SYSTEM OF SOLUBLE PACLITAXEL COMPLEX

Main Article Content

Sachin Devidas Rede , Dr. Rupal K. Jani
» doi: 10.31838/ecb/2023.12.s1-B.215

Abstract

A number of novel vesicular drug delivery systems have been emerged encompassing various routes of administration, to achieve targeted and controlled drug deliveryi.Targeted drug delivery is a mode of delivering the therapeutic agent to the tissues of interest while reducing the relative concentration of therapeutic agent in remaining tissues which improves the therapeutic efficacy and reduces the side effects. MATERIALS AND METHODS Liposome was prepared with the help of PTX-HA, Phosphatidylcholine, Cholesterol, Tween 80, PBS, PEG-400. Different process parameter like RPM, Temperature, Time was observed during experiment. PTX-HA Loaded Liposome was prepared. The hepatoprotective activity of pure PTX and PTX-HA complex was performed in Wistar albino rats.RESULT AND DISCUSSION Due to poor solubility of PTX, there was low bioavailability and inappropriate tissue localization of PTX that could not show prominent hepatoprotective activity on CCl4 administration. Histopathological study also confirmed a slight diffused liver but with prominent area of hepatocytic cell regeneration. The HA-treated group showed elevated levels of SGOT, SGPT, and ALP (347.67±13.17 U/l, 96.93±8.586 U/l, and 457.06± 16.7 U/l, respectively) same as a toxic group. This indicated that HA did not contribute to hepatoprotective effect as PTX, and at the same time, it did not cause any increase in toxicity. This finding establishes the safety of HA towards liver and promotes it as a valuable pharmaceutical material Significant decrease was observed in serum parameters upon administration of PTX–HA complex when compared to toxic group. CONCLUSION It suggested that the complexed form of PTX demonstrated better hepatoprotective activity as compared to free PTX. This might be due to higher solubility of PTX in the complexed form, which caused complete availability for the hepatoprotective action.

Article Details