Present study was conducted to develop formulation of Glipizide using high viscosity grades of hydroxypropyl methylcellulose (hydrophilic). All the polymers were incorporated separately in the matrix system using wet granulation technique. A32 full factorial design was employed for the optimization of formulation. The granules were prepared by wet granulation method and thereby formulated as F1 to F9 by using the above bring up polymers with other ingredients. The granules of different formulations were evaluated for angle of repose, loose bulk density and tapped density, compressibility index, and drug content. Technological characterizations thickness, diameter, weight variation test, drug content, hardness, and friability were conceded with the formulated matrix tablet and in- vitro drug release was measured by means of dissolution apparatus USP Type II (paddle) using the phosphate buffer pH 7.4. Formulation F8 was subjected to stability was accomplished studies for three months at 300C/65%RH and 400C/75%RH. The kinetic release model showed that the release of drug follows zero order kinetic. Thus the result suggest the developed sustained release tablets of Glipizide performed therapeutically better than conventional dosage form, leading to increased half-life, therapeutic efficacy with better patient compliance.