The aim of this study was to create a tablet for reducing lipid levels in the blood, which would contain nanosponges and be designed to release the drug in a pulsatile manner. The emulsion solvent evaporation was used to develop SIM loaded nanosponges with the use of analytical grade of chemical and reagents and direct compression method was used to formulate tablet. The findings indicate that the concentration of polymers has increased. increased the effectiveness of drug entrapment, but after a certain concentration, as polymer concentration rose, entrapment effectiveness fell. In comparison to other formulations, F5 (90.048%) and F6 (86.52%) were found to have superior entrapment efficiency. The formulations F5 and F6 were selected as the most favorable options because of their higher entrapment efficiency and prolonged drug release duration in the in vitro experiments. The objective of this research was to develop nanosponges of Simvastatin, a drug with low solubility and short half-life, to achieve controlled release, improve solubility, reduce adverse effects that depend on dosage, and increase patient adherence.