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ISSN 2063-5346
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FORMULATION AND EVALUATION OF PUSH-PULL OSMOTIC PUMP TABLETS OF MANGIFERIN

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Badri Nagarani , Dr.G.V.Radha
» doi: 10.31838/ecb/2023.12.3.102

Abstract

Mangiferin is a xanthone compound which is abundantly present in mango leaves and has antidiabetic and other pharmacological activities. The goal is to design and evaluate a push-pull osmotic drug delivery system for mangiferin. A push-pull osmotic pump tablet is a dual-layer tablet comprising of a pull layer (drug layer) & a push layer (osmosis source layer), covered with a semipermeable membrane having water extractant and a blowing agent. The formulation was formulated using wet granulation techniques. Opadry CA was used as a film-forming polymerSodium chloride has been used as an osmotic agent. When these systems come into contact with the medium, PEO produces viscous gel and controls the release of the drug, while sodium chloride enhances drug release. in the pressure traction system. The pressure pad expands and releases the medication at a controlled rate. All pre- and post-compression settings are displayed within limits.

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